Approximately 1,700 scientists visit SSRL annually to conduct experiments in broad disciplines including life sciences, materials, environmental science, and accelerator physics. Science highlights featured here and in our monthly newsletter, Headlines, increase the visibility of user science as well as the important contribution of SSRL in facilitating basic and applied scientific research. Many of these scientific highlights have been included in reports to funding agencies and have been picked up by other media. Users are strongly encouraged to contact us when exciting results are about to be published. We can work with users and the SLAC Office of Communication to develop the story and to communicate user research findings to a much broader audience.
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Structure-guided Nanobodies Block SARS-CoV-2 Infection
A potential treatment for COVID-19 patients is administering monoclonal antibodies, which can directly neutralize virus by interacting with its spike protein. Monoclonal antibodies are identified from patients or lab animals that have been exposed to the virus and manufactured in larger quantities to treat patients.
Iron Heterogeneity in Early Active Multiple Sclerosis Lesions
Evidence gathered over the last 40 years suggests that a diagnosis of multiple sclerosis (MS) includes different types of diseases, but MS is usually treated as one disease. MS is defined by a loss of myelin that surrounds the axons of neurons and inflammation, which leads to serious outcomes like paralysis, blindness, and bowel and bladder problems.
Designing a Higher-Order Topological Insulator Composed of Bismuth-Halide Chains
Spintronics is analogous to electronics, where an electron’s spin state is used to store information rather than, or in addition to, the charge. Potential uses for spintronics include storing information in electron spin, which is not disturbed by magnetic fields nor affects neighboring electrons like electron charge.
Copper and Zinc Forms in Bottom Ash from Solid Waste Incineration
When trash is burned for energy, a residue called bottom ash (BA) is left behind. Each year the European Union alone creates millions of tons of BA, which can be used for construction after treatment. It is concerning that BA may contain metals like copper and zinc that leach into the environment, potentially harming wild life and, people.
Evidence for a Dynamic Mo-nitrogenase Metallocofactor during Dinitrogen Reduction
Nitrogen is an essential component for life and often a limiting factor for growth, despite the fact that air is composed of mostly nitrogen. The processing required to turn dinitrogen (N2) gas into a form usable by most living organisms is rare in nature. Breaking the triple bond of N2 requires the enzyme nitrogenase, which is found in some bacteria.
Reversible Multicolor Chromism in Layered Formamidinium Metal Halide Perovskites
Switchable photovoltaic windows hold much promise as a new technology to mitigate greenhouse gases that cause climate change. These windows not only automatically and reversibly darken to decrease the need for air conditioning, they generate electricity. One promising active layer is based on metal halide perovskites (MHP), a crystalline material that can harness sunlight.
Mutual Modulation between Surface Chemistry and Bulk Microstructure within Secondary Particles of Nickel-rich Layered Oxides
Lithium ion battery technology has made possible our most-used personal electronics. Improvements in lithium ion battery energy storage, which can lead to advancements in technologies like electric vehicles, depend largely on improvements to the cathode materials.
The Making of an Enzyme-in-Action Movie
The enzyme 3-Hydroxyanthranilate-3,4-dioxygenase (HAO) is critical for the metabolism of the amino acid tryptophan and the synthesis of the important coenzyme nicotinamide adenine dinucleotide (NAD+). Although the role of this enzyme has been long known, its mechanism and regulation have remained a mystery, because it is difficult to study.
Modern Methods Applied to a Past Poisoning at Minamata Japan
In the 1950’s and 60’s a poisoning occurred in Minamata Japan. In addition to the people, the local cat population was affected with what was called “Dancing Cat Disease” and shortly thereafter neurological signs and symptoms became more prominent in people. The sickness became known as Minamata Disease. Eventually it was shown to be a form of organic mercury poisoning.
SARS-CoV-2 Spike Protein Targeted for Vaccine
The COVID-19 pandemic triggered by the SARS-CoV-2 coronavirus is causing health and economic havoc on a global scale requiring the development of an effective vaccine and therapeutics. Spike proteins found on the viral surface of SARS-CoV-2 attach to human cells to gain entry.
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We can work with users and the SLAC Office of Communication to develop the story and to communicate user research findings to a much broader audience.